MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis
نویسندگان
چکیده
منابع مشابه
MicroRNAs in angiogenesis and vascular smooth muscle cell function.
The Human Genome Project was barely completed in 2003 before a new quest was launched: this time, in a search for short stretches of RNA called microRNA. The belief that these miniature molecules, which had only been discovered a decade earlier, were major regulators of genetic function gained momentum in the intervening years and sparked a worldwide interest in the physiologic and pathologic r...
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RATIONALE MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown. OBJECTIVE The aim of the present study was to evaluate the role, if any, of miR-1 and miR-133 in vascular smooth muscle cell (VSMC) phenotypic switch in vitro and in vivo. ME...
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Fyn, a member of the Src family kinases (SFKs), has a pivotal role in cell adhesion, proliferation, migration and survival, and its overexpression is associated with several types of cancer. MicroRNAs (miRNAs) play a major role in post-transcriptional repression of protein expression. In light of the significant functions of Fyn, together with studies demonstrating miR-125a as a tumor-suppressi...
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Although smooth muscle cells participate in the remodeling associated with atherosclerosis and other vascular diseases, the mechanisms by which these cells interact with their mechanical environment are incompletely characterized. This thesis serves to elucidate the capacity of smooth muscle cells to modulate their matrix and respond to mechanical loading. Because integrins mediate many cell-ma...
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The discovery of small noncoding microRNAs (miRNAs) increases the complexity of gene expression regulatory mechanisms. The basic mechanism of miRNA biogenesis and regulatory functions of target genes have been widely elucidated. Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs. Interestingly, cell signaling pathways, ...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2019
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2019.08.014